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Volume 81, Number 04, 2010 | | Other |
The estimation of the probability of tumor malignacy on the basis of test combination in the primary diagnosis of adnexal tumorsSummary
Purpose: The aim was to evaluate the risk of ovarian tumor malignancy based on logistic regression analysis and to construct a practical tool which might be used at the bedside.
Material and methods: 379 women with adnexal masses were enrolled to the study. The results of the twodimensional (2D) gray-scale ultrasound examination, color and spectral Doppler blood flow measurement, threedimensional (3D) sonoangiography examination and serum levels of CA-125 measurement were analyzed. 160 out of 379 women with abnormal findings, (42.2%), were diagnosed with a malignant ovarian tumor, and 219 (57.8%) were found to have a non-malignant adnexal mass. To improve the sensitivity and specificity of ultrasound scan findings, postmenopausal status and preoperative serum CA-125 levels, the risk of malignancy index (RMI) was calculated and compared to the result of logistic regression analysis. Furthermore, the nomograms applicable at the bedside for estimation of the probability of malignancy for the examined adnexal tumor were derived.
Results: The highest values of the area under the receiver operating characteristic (ROC) curves in univariate analysis were 0.87 for serum levels of CA-125 and 0. 83 for the color score. For the RML, the value of the area under ROC curve was 0.91. The results of logistic regression revealed that papillary growth, color score, age, pulsatility index (PI) and level of serum CA 125 were significant factors in the multivariate model. The obtained classification accuracies for MLRA model in the training set and the test set were 88% and 92%, respectively. The value of the area under the ROC curve was 0.94 and significantly differed from the value of area for CA-125 (p<0.05).
Conclusions: The results of the study suggest that the combined use of ultrasound parameters and serum level of CA-125 in the prognostic model improves the diagnostic precision in the primary discrimination of benign and malignant ovarian tumors in women.
Agata Smoleń, Norbert Stachowicz, Artur Czekierdowski, Jan Kotarski
Ginekol Pol 2010; 81(04):254-261
ICID: 911019
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IC™ Value: 6.50 | |
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Validity and reliability of the quality of life questionnaire (EORTC QLQ C30) and its breast cancer module (EORTC QLQ BR23)
Katarzyna Zawisza, Beata Tobiasz-Adamczyk, Wojciech Nowak, Jan Kulig, Joanna Jędrys
Ginekol Pol 2010; 81(04):262-267
ICID: 911020
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IC™ Value: 6.50 | |
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hBD-1 and hBD-2 are expressed in cervico-vaginal lavage in female genital tract due to microbial infections
Barbara Wiechuła, Krzysztof Cholewa, Alicja Ekiel, Małgorzata Romanik, Hanna Doleżych, Gayane Martirosian
Ginekol Pol 2010; 81(04):268-271
ICID: 911021
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IC™ Value: 6.50 | |
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The role of fetal nuchal translucency (NT) and ductus venosus blood flow (DV) in the detection of congenital heart defects
Elżbieta Baś-Budecka, Małgorzata Perenc, Piotr Sieroszewski
Ginekol Pol 2010; 81(04):272-276
ICID: 911022
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IC™ Value: 6.50 | |
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The impact of premature rupture of membranes (PROM) on neonatal outcome
Agnieszka Plucińska, Maria Hajduczenia, Małgorzata Pastusiak, Marta Kowalik, Izabela Miechowicz, Marta Szymankiewicz
Ginekol Pol 2010; 81(04):277-282
ICID: 911023
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IC™ Value: 6.50 | |
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Diagnosis and treatment of pulmonary embolism in pregnancy
Maciej Kostrubiec, Nikola Niewęgłowska, Piotr Pruszczyk
Ginekol Pol 2010; 81(04):283-286
ICID: 911024
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IC™ Value: 5.20 | |
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Vaginal birth after cesarean delivery
Tomasz Kostrzewa, Joanna Walczak, Katarzyna Więckowska
Ginekol Pol 2010; 81(04):287-291
ICID: 911025
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IC™ Value: 5.20 | |
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A review of cardiovascular complications of pregnancy
Huriye Parlakgumus, Bulent Haydardedeoglu
Ginekol Pol 2010; 81(04):292-297
ICID: 911026
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IC™ Value: 5.20 | |
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Hypertrophy of labia minora – pathomorphology and surgical treatment
Julia Kruk-Jeronim, Tomasz Zieliński
Ginekol Pol 2010; 81(04):298-302
ICID: 911027
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IC™ Value: 6.50 | |
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Partial uterine rupture – case report
Wacław Sikora, Zenon Michalak, Dobrosława Sikora-Szczęśniak
Ginekol Pol 2010; 81(04):303-304
ICID: 911028
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IC™ Value: 3.90 | |
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Megacystis in a fetus – description of 3 clinical cases
Jakub Kornacki, Jana Skrzypczak
Ginekol Pol 2010; 81(04):305-310
ICID: 911029
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IC™ Value: 3.90 | |
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Low-weight heparin treatment in obstetrics and gynecology – the Polish Gynecological Society
Array
Ginekol Pol 2010; 81(04):311-314
ICID: 911030
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IC™ Value: 5.20 | |
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